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งานวิจัย & นวัตกรรม

  • Mesenchymal stem cell-mediated cancer therapy

  • Mesenchymal stem cell-mediated cancer therapy

  • Mesenchymal stem cell-mediated cancer therapy: A dual- targeted strategy of personalized medicine

    Xu-Yong Sun, Jiang Nong, Ke Qin, Garth L Warnock, Long-Jun Dai

    Cancer remains one of the leading causes of mortality
    and morbidity throughout the world. To a significant
    extent, current conventional cancer therapies are
    symptomatic and passive in nature. The major obstacle
    to the development of effective cancer therapy is be lieved to be the absence of sufficient specificity.

    Since the discovery of the tumor-oriented homing capacity
    of mesenchymal stem cells (MSCs), the application of
    specific anticancer gene-engineered MSCs has held
    great potential for cancer therapies. The dual-targeted
    strategy is based on MSCs’ capacity of tumor-directed
    migration and incorporation and in situ expression of
    tumor-specific anticancer genes. With the aim of translating
    bench work into meaningful clinical applications,
    we describe the tumor tropism of MSCs and their use
    as therapeutic vehicles, the dual-targeted anticancer
    potential of engineered MSCs and a putative personalized
    strategy with anticancer gene-engineered MSCs.