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  • Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

  • Immunomodulatory properties of stem cells from human exfoliated deciduous teeth

  • Immunomodulatory properties of stem cells from human exfoliated deciduous teeth
     

    Human bone marrow mesenchymal stem cells
    (BMMSCs) have been identified as a population of
    postnatal stem cells with the potential to self-renew and
    differentiate into osteoblasts, chondrocytes, adipocytes,
    and neural cells [1-5]. BMMSCs also exhibit immunomodulatory
    and regulatory effects on T and B lymphocytes,
    dendritic cells, and natural killer cells, indicating
    an attractive feature for cell therapy [6-11]. In addition,
    culture expanded BMMSCs may fail to express MHC-
    class II antigens on their surfaces, therefore allogenic
    BMMSCs have been used in treating a variety of diseases
    such as acute graft-versus-host-disease (GVHD) [12-14],
    ameliorating
    Hematopoietic Stem Cell engraftment [15,
    16], and systemic lupus erythematosus (SLE) [17].
    Recently, mesenchymal stem cells derived from other
    tissues have also been found to possess immunomodulatory
    functions [18-20] which offer opportunities
    to find more effective and feasible mesenchymal stem cell
    sources for cell therapies.

    Stem cells from human exfoliated deciduous teeth
    (SHED) have been isolated from naturally exfoliated
    deciduous teeth with the capacity to differentiate into
    osteogenic and odontogenic cells, adipocytes, and neural
    cells [21]. As neural crest cell-associated postnatal stem
    cells, SHED express a variety of neural cell markers
    including nestin, beta III tubulin, GAD, NeuN, GFAP,
    NFM, and CNPase [21]. Also, SHED are able to form
    bone when transplanted in vivo [22] and offer obvious
    bone regeneration for repairing calvarial defects in a
    mouse model [23]. It is unknown whether SHED possess